Stem Cell Bank

Cellivia – Stem Cell Bank company

1. A visit to the dentist

The material for banking is collected on the occasion of standard dental procedures such as
extraction of a milk tooth, removal of permanent retained teeth or teeth extracted for orthodontic
reasons and during implantation procedures.
The extracted tooth or piece of gingiva or bone chip is protected by a trained dentist and placed in a
special container ready for transport.
The whole procedure is based on the fact that the material that was normally thrown to biological
waste, in this office is secured by a dentist and sent for examination and then if the procedure was
effective for banking.
2. Procedures for obtaining stem cells from dental pulp, i.e. laboratory procedures in vitro
After removing the pulp from the teeth, the tissue fragment is subjected to a series of laboratory
procedures aimed at obtaining a selected, specific and highly homogeneous population of stem cells.
After selecting a specific population of cells, the stem cells are then genetically tested for the
presence of pluripotency markers as well as in terms of biosafety. During all procedures and analyzes
performed in the laboratory, we use only certified test equipment and certified and biologically safe
chemical reagents. The next step is to decide whether stem cells in this form will be directed to long-
term storage (freezing) in the Stem Cell Bank, or whether a procedure for targeting stem cell
development to other highly specialized cell types will be launched.

3. Examination of stem cell properties
Cells isolated from the pulp of teeth during tests performed in the laboratory are subjected to
analysis determining their degree of pluripotency. These tests are performed using the latest genetic
techniques, cell and molecular biology. The results of these advanced analyzes provide us with
information on the extent to which the population of cells we have isolated from the dental pulp is a
homogeneous population of stem cells. The Cellivia researchers, based on many years of experience
and the latest literature data, have developed proprietary procedures thanks to which, by selecting
the right genetic markers, we can quickly determine the usefulness and value of the stem cells
obtained in a very short time. Our technology for obtaining stem cells from the dental pulp gives us
100% confidence in the quality of isolated cells. By performing all laboratory procedures and analyzes
we strictly follow the principle of biological safety of handling biological material. As a result, the
products offered to our clients are of the highest quality

4. Long-term storage of cells in the Stem Cell Bank

Stem cells isolated from the dental pulp after confirming the value of their pluripotency and the
implementation of biosafety procedures are directed to long-term storage (freezing) in the Stem Cell
Bank. The Stem Cell Bank belonging to Cellivia is a certified commercial unit. The bank meets all the
requirements of biological safety and is fully dedicated to long-term storage (freezing) of various
types of human cells, including primary human stem cells.
Long-term stem cells isolated from human dental pulp constitute our invaluable health insurance for
the future. Tooth pulp cells are an alternative to umbilical cord blood stem cells due to their non-
invasive collection during routine procedures performed in a dental office. In addition, we can take
them from the milk teeth of children and adults from retained teeth. Undoubtedly, the great
advantage of these cells is the fact that we can take them several times from one patient.
It is particularly important to store stem cells obtained from milk teeth in children. What is necessary
to this is only the awareness of parents about the potential of their child’s dental stem cells and a
one-time visit to the dentist.
The potential of oral stem cells is unique – therapies in neurodegenerative disease, nerves
regeneration, diabetes I therapies, bone and cartilage regeneration, periodontal disease therapies.
Additionally morphological analysis of tooth structure can be an early predictor of ni disorders.
Stem cell therapies are the beginning of the personalized medicine era.

5. Biological safety tests and certificates, and therefore what requirements must be met in order to
be able to store stem cells in the Bank

Cellivia Stem Cell Bank has all the certificates and meets all the regulations of biological safety. Stem
cells isolated from the pulp of both children and adults are checked for biological safety
requirements. This means that before running the procedure of long-term storage (freezing) of cells,
genetic tests are performed for the presence of infection with viruses, bacteria and fungi. Only stem
cells that meet all strict biosecurity requirements are directed to the freezing procedure at the Stem
Cell Bank. During the safety tests, Cellivia scientists use only certified reagent kits dedicated to
medical diagnosis. Thanks to this, we obtain 100% certainty about the biological purity of stem cells
stored in our Stem Cell Bank.
Our ultimate goal is the reliability of our research, customer trust and security.

6. Summary, from the dental office to the Stem Cell Bank
The collection of stem cells is a “side effect” of standard dental procedures . All you need to do is fill
in a short document that is a declaration of stem cell freezing in the Stem Cell Bank, and inform the
dentist about this in order to properly secure the extracted material and send it to the Cellivia
laboratory.

Cellivia means health, quality and safety